Real-time volumetric lipid imaging in vivo by intravascular photoacoustics at 20 frames per second.

نویسندگان

  • Min Wu
  • Geert Springeling
  • Matija Lovrak
  • Frits Mastik
  • Sophinese Iskander-Rizk
  • Tianshi Wang
  • Heleen M M van Beusekom
  • A F W van der Steen
  • Gijs Van Soest
چکیده

Lipid deposition can be assessed with combined intravascular photoacoustic/ultrasound (IVPA/US) imaging. To date, the clinical translation of IVPA/US imaging has been stalled by a low imaging speed and catheter complexity. In this paper, we demonstrate imaging of lipid targets in swine coronary arteries in vivo, at a clinically useful frame rate of 20 s-1. We confirmed image contrast for atherosclerotic plaque in human samples ex vivo. The system is on a mobile platform and provides real-time data visualization during acquisition. We achieved an IVPA signal-to-noise ratio of 20 dB. These data show that clinical translation of IVPA is possible in principle.

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عنوان ژورنال:
  • Biomedical optics express

دوره 8 2  شماره 

صفحات  -

تاریخ انتشار 2017